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Co. Looks to New Structures of Psychedelic Drug for Strokes

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The Quick Take

  • Algernon Pharmaceuticals Inc. disclosed that it included novel salt forms of N,N-dimethyltryptamine (DMT) in its intellectual property patent applications for the drug, which were filed in early 2021.
  • DMT is a psychedelic compound that may help repair the brain after a stroke.
  • A novel salt form of a drug is a new and separate structure from the original compound.
  • Pairing different salts with a compound's core structure can improve the efficacy, safety, tolerability, and stability of a drug, the company said.
  • Algernon also announced on Jan. 18 that it has filed an application with the United Kingdom Medicines and Healthcare Products Regulatory Agency for its planned Phase 1 DMT clinical human stroke study.

Algernon Pharmaceuticals Inc. (AGN:CSE; AGNPF:OTCQB; AGW:FSE) said it believes it has maximized its intellectual property for DMT by filing dosing, formulation, and method of use patent applications for stroke rehabilitation with the drug.

A preclinical animal study has shown that DMT — which produces effects similar to other psychedelics like LSD, ketamine, psilocybin, and psilocin — helps the brain form and reorganize the synaptic connections needed for healing after a stroke, Algernon said.

The company said DMT occurs naturally and has been used in religious ceremonies as a traditional spiritual medicine by indigenous people in the Amazon basin. It can also be synthesized in a laboratory.

Algernon specializes in finding new applications for already approved drugs or naturally occurring compounds. It specifically looks at compounds that have not been approved in the United States or Europe to avoid off-label prescription writing.



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