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News Update


Pharma Developer Contemplates Adding Lung Scarring as Key Endpoint in Phase 2b/3 COVID-19 Trial
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Algernon Pharmaceuticals reported it is considering adding "lung scarring" as an additional primary endpoint to its Phase 2b/3 COVID-19 Ifenprodil study protocol.

Algernon Pharmaceuticals Inc. (AGN:CSE; AGNPF:OTCQB; AGW:FSE) announced in a news release that "it has decided to review its protocol for its phase 2b/3 study of Ifenprodil for COVID-19, to consider adding lung scarring as an additional endpoint if sufficient data is available from a significant number of patients."

The company stated that when it initially prepared the original phase 2b/3 protocol in April of 2020, it did not include lung scarring subsequent to hospitalization as a key primary endpoint because at that time the issue had not yet been identified as a major, frequently experienced problem in recovering COVID-19 patients.

The firm advised that while most hospitals' standard of care calls for a chest X-ray to be performed upon admission of a COVID-19 patient, not all will take an X-ray prior to discharging a patient because they rely on other clinical markers as part of their site-specific standard of care methods.

Algernon Pharmaceuticals' CEO Christopher J. Moreau remarked, "If we determine that X-rays were taken on release of a meaningful number of our treated patients, and Ifenprodil is showing a reduction in the amount of scarring post infection, this would be an extremely important discovery for us...If this is confirmed in the planned Phase 3 portion of the study, it would mean that Ifenprodil could be used to treat patients who have survived COVID-19 but are suffering from lung damage."

The company stated that according to results published by Oxford University scientists in October 2020 from the recent C-MORE Study, on MRI, tissue signal abnormalities such as scarring and inflammation were seen in the lungs of 60% of the COVID-19 patients three months after clearing the virus.

Algernon Pharmaceuticals indicated that at this time it is not making claims of any kind regarding the ability of Ifenprodil to contain, cure or eliminate SARS-CoV-2, which is commonly referred to as COVID-19 or the coronavirus.


1) Stephen Hytha compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. He or members of his household own securities of the following companies mentioned in the article: None. He or members of his household are paid by the following companies mentioned in this article: None.
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