Expert Comments:

Possible 'Best-in-Class' Alzheimer's Drug Candidate Offers 'Disruptive' Potential (9/20/17) André Uddin, an analyst with Mackie Research, explained the rationale for adding this neurodegenerative disease biotech company to his firm's coverage universe. read more >
André Uddin, Mackie Research Capital (9/19/17) "We are initiating coverage of Promis Neurosciences Inc. . .a promising new path for targeting Alzheimer's (AD). A therapy to treat the underlying cause of Alzheimer's disease represents an enormous market opportunity. . .Promis' lead mAb (monoclonal antibody) drug candidate, PMN310, was rationally designed to target toxic amyloid beta (AB) oligomers. AB is a “sticky” peptide (monomer) which clumps together to form toxic oligomers, which can in turn form plaque deposits. . .this newer theory is strongly backed by the Phase 1b success of Biogen's aducanumab which targets toxic AB oligomers. . .we believe this newer AD theory creates a path to develop a unique disease-modifying Alzheimer's treatment, PMN310 which has best-in-class potential."
	Douglas Loe, Echelon Wealth Partners (9/13/17) "ProMIS Neurosciences Inc. announced that a third therapy has been identified for the firm's Alzheimer's disease pipeline. The asset in question is PMN330, a mAb targeting amyloid-beta oligomers, and we assume the mAb is one of many based on CSO Neil Cashman's expertise in developing mAbs that target misfolded protein antigens. . .the asset will join two other identified lead compounds PMN310 and PMN350, with PMN310 still set to be the first lead asset to enter formal clinical trials by 2019."
Biotech with Alzheimer's Focus Makes Progress on Several Fronts (7/18/17) In its corporate update for Q2/17, a Canada-based biotech targeting neurological disorders including Alzheimer's disease informed investors of advancements in several programs, including designation of a second validated lead compound in development. read more >
Management Q&A: View From the Top The ProMIS of an Alzheimer's Cure (5/3/17) With the impacts of Alzheimer's disease on patients, doctors and the health care industry expected to burgeon over the next decade, ProMIS Neurosciences has developed a preclinical program that targets the root cause of the disease, and also offers the potential to get in on an investment with a double bottom line, says Elliot Goldstein, CEO of ProMIS, in this interview with The Life Sciences Report. read more >
	Eden Rahim, Next Edge Capital (4/5/17) "ProMIS Neurosciences Inc. is a preclinical company, but it will be going in the clinic over the next year or so. I'm in it because of some of the really important insights it has discovered into the mechanism of action of Alzheimer's disease. What ProMIS has discovered is that the ideal thing to target for Alzheimer's is soluble amyloid beta oligomers. It believes that they are the root cause of Alzheimer's, not the plaque that ultimately settles on the brain. ProMIS has discovered that by focusing on IgG 4 isotype, you can circumvent the inflammation that often comes with monoclonal antibodies. ProMIS has identified six epitopes on protein strains of misfolded amyloid precursor proteins (APPs). APPs are the misfolded proteins that eventually lead to something called fibrils, which eventually clot and form plaques in the brain. ProMIS has discovered that the prion strains of those misfolded proteins carry a marker, called an epitope. It's like a police car with a light on top. ProMIS has developed five murine antibodies that select for those epitopes so antibodies can find them on those misfolded proteins and bind to them. It is actually a pretty profound breakthrough at this level. Again, it's very early stage and preclinical. But ProMIS has selected one of those five antibodies. The drug that it's going to advance, PMN-310, will be its first candidate in clinic. I bought into ProMIS on a financing in the summer of 2015. I'll probably hold it for another 5 or 10 years. It's achieved a lot with very little, and its understanding of the mechanism of action of Alzheimer's is quite significant. I think we'll hear about that over the course of 2017." read more >

Experts Following This Company

	Douglas Loe, Analyst – Echelon Wealth Partners
	Eden Rahim, Portfolio Manager and Options Strategist – Next Edge Capital
André Uddin – Mackie Research Capital

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