In a news release, Revive Therapeutics Ltd. (RVV:TSX.V; RVVTF:OTCMKTS) announced it appointed John Fahy, MD, MSc, as a scientific and clinical adviser to help expand and analyze the data from the ongoing Phase 3 clinical trial evaluating Bucillamine as a treatment for patients with mild to moderate COVID-19.
"Dr. Fahy is a distinguished clinical researcher with thiol-based drugs, such as Bucillamine, and his understanding of its mechanism of action and how it relates to SARS-CoV-2 will be valuable in assessing our interim analysis of our U.S. Food and Drug Administration Phase 3 study," Revive CEO Michael Frank said in the release.
Fahy wrote the recently published article "Thiol-Based Drugs Decrease Binding of SARS-CoV-2 Spike Protein to its Receptor and Inhibit SARS-CoV-2 Cell Entry." He is a professor of medicine at the University of California, San Francisco's (UCSF's) Division of Pulmonary and Critical Care Medicine and holds the Michael S. Stulbarg Endowed Chair in Pulmonary Medicine there. Also, Fahy is the director of UCSF's Asthma Clinic and its Airway Clinical Research Center.
After obtaining a medical degree from the University College Dublin in Ireland, he completed a fellowship in pulmonary and critical care medicine at UCSF.
"Bucillamine, a cysteine derivative with two thiol groups, has been shown to be 16 times more potent as a thiol donor in vivo than N-acetyl-cysteine. Bucillamine has a well-known safety profile with over 30 years of use as a treatment for rheumatoid arthritis in Japan and South Korea," the company stated.
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