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News Update

TICKERS: AGN; AGNPF; AGW

Pharma Greenlighted to Continue Multinational COVID-19 Study
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This confirms the safety of NP-120, the drug Algernon Pharmaceuticals is evaluating in this human trial.

Algernon Pharmaceuticals Inc. (AGN:CSE; AGNPF:OTCQB; AGW:FSE) announced in a news release the Data and Safety Monitoring Board (DSMB) approved continuation of its multinational Phase 2b/3 clinical trial of NP-120, or Ifenprodil, as a COVID-19 treatment.

This decision "confirms what we had previously identified regarding Ifenprodil's longstanding safety history," Algernon Pharmaceuticals CEO Christopher J. Moreau said in the release.

The Phase 2b portion of the study is currently in progress. "Patients are being randomized in a one-to-one manner and are either being treated using an existing standard of care, or standard of care plus Ifenprodil 60 mg (taken as one 20 mg tablet three-times daily) for one arm or standard of care plus Ifenprodil 120 mg (taken as two 20 mg tablets three-times daily) for two weeks," the company stated. "Over the testing period, doctors will observe whether there is an improvement in a number of secondary endpoints, including mortality, blood oxygen levels, time spent in intensive care and time to mechanical ventilation."

The company noted that the cytokine storm that leads to COVID-19-associated loss of lung function and death results from T-cells releasing cytokines in the lungs. Vancouver-based Algernon believes that Ifenprodil, an NMDA inhibitor, can reduce the release of cytokines in the lungs.

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Disclosure:
1) Doresa Banning compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. She or members of her household own securities of the following companies mentioned in the article: None. She or members of her household are paid by the following companies mentioned in this article: None.
2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: Algernon Pharmaceuticals. Click here for important disclosures about sponsor fees. As of the date of this article, an affiliate of Streetwise Reports has a consulting relationship with Algernon Pharmaceuticals. Please click here for more information.
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5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the decision to publish an article until three business days after the publication of the article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases. As of the date of this article, officers and/or employees of Streetwise Reports LLC (including members of their household) own securities of Algernon Pharmaceuticals, a company mentioned in this article.




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