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Biopharma Advances Dose Escalation Trial in Alcoholic Hepatitis
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The company received approval to proceed with the next and final dose level.

DURECT Corp. (DRRX:NASDAQ) announced in a news release two pieces of news concerning progress of its ongoing DUR-928 Phase 2a clinical trial in patients with moderate and patients with severe alcoholic hepatitis.

First, the company finished dosing the severe alcoholic hepatitis patients receiving 90 milligrams (90 mg) of DUR-928.

Second, the dose escalation committee approved moving into the 150 mg dose part of the study. Enrollment for this final dose level cohort, also patients with severe alcoholic hepatitis, will begin soon.

The committee gave the green light after reviewing safety and pharmacokinetic data from the already completed dose cohorts. "Preliminary data from the completed cohort of severe alcoholic hepatitis patients dosed at 90 mg are consistent with the preliminary data from 30 mg and 90 mg patients we reported last month," President and CEO James E. Brown said in the release.


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