ProMIS Neurosciences Inc. (PMN:TSX; ARFXF:OTCQB) announced in a news release it will present data during the poster session at the Keystone Symposium on Neurodegenerative Diseases: New Insights and Therapeutic Opportunities to be held June 16 to 19, 2019, in Colorado.
The topic of Chief Development Officer Dr. Johanne Kaplan's presentation will be PMN310, ProMIS' lead candidate and monoclonal antibody for Alzheimer's disease and will encompass key data showing how PMN310 selectively targets toxic forms of amyloid beta, believed to be a root case of the disease.
Along with PMN310's superior selectivity for amyloid beta toxic oligomers, the data will show that PMN310 could possibly be administered at high doses safely, with a reduced risk of brain swelling or amyloid-related imaging abnormality, and could potentially cause greater therapeutic effect than other amyloid beta-targeted antibodies. PMN310 is currently in advanced preclinical development.
"Evidence continues to mount, showing that amyloid-beta toxic oligomers, not amyloid plaque, are the key target for Alzheimer's disease therapy," Kaplan said in the release. "Our data will demonstrate the unique ability of the ProMIS discovery platform to generate antibodies that bind the toxic species of amyloid beta while preserving healthy forms of the protein."
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