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Trial Milestone Reached; U.K.-Based Biopharma Gets $15 Million
Research Report

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The first patient has been treated in the second cohort of a Phase 2 study of a gene therapy targeting Parkinson's disease, explained an H.C. Wainwright & Co. report.

In an April 30 research note, analyst Joseph Pantginis reported that Oxford Biomedica Plc (OXB:LSE) received a $15 million milestone payment from its partner Axovant.

The achievement that triggered the payment was Axovant having treated the first patient in the second cohort of the Phase 2 SUNRISE-PD clinical trial, in which the AXO-Lenti-PD gene therapy is being evaluated in Parkinson's disease patients. Up to six patients are to be enrolled in this group, with initial data expected in Q4/19, Pantginis explained.

That first patient of the second cohort, whom Axovant recently dosed, did not suffer any complications from surgery or administration of the therapeutic and was subsequently discharged, relayed Pantginis. There were not any associated serious adverse events.

This initial safety report is encouraging, the analyst wrote, and if further substantiated, could potentially result in efficacy data being gathered quickly and development of AXO-Lenti-PD being accelerated. "Overall, we are confident the PD program is going to generate meaningful data," he noted.

Pantginis added that due to a paucity of any existing therapy that effectively slows or reverses Parkinson's disease progression, AXO-Lenti-PD could be a potential new gene therapy for it.

H.C. Wainwright has a Buy rating and a £14.50 per share target price on Oxford Biomedica, whose current share price is around £6.96.


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Disclosures from H. C. Wainwright, Oxford Biomedica Plc, First Take, April 30, 2019

Investment Banking Services include, but are not limited to, acting as a manager/co-manager in the underwriting or placement of securities, acting as financial advisor, and/or providing corporate finance or capital markets-related services to a company or one of its affiliates or subsidiaries within the past 12 months.

I, Joseph Pantginis, Ph.D., certify that 1) all of the views expressed in this report accurately reflect my personal views about any and all subject securities or issuers discussed; and 2) no part of my compensation was, is, or will be directly or indirectly related to the specific recommendation or views expressed in this research report; and 3) neither myself nor any members of my household is an officer, director or advisory board member of these companies.

None of the research analysts or the research analyst’s household has a financial interest in the securities of Oxford BioMedica PLC (including, without limitation, any option, right, warrant, future, long or short position).

As of March 31, 2019 neither the Firm nor its affiliates beneficially own 1% or more of any class of common equity securities of Oxford BioMedica PLC.

Neither the research analyst nor the Firm has any material conflict of interest in of which the research analyst knows or has reason to know at the time of publication of this research report.

The research analyst principally responsible for preparation of the report does not receive compensation that is based upon any specific investment banking services or transaction but is compensated based on factors including total revenue and profitability of the Firm, a substantial portion of which is derived from investment banking services.

The Firm or its affiliates did not receive compensation from Oxford BioMedica PLC for investment banking services within twelve months before, but will seek compensation from the companies mentioned in this report for investment banking services within three months following publication of the research report.

The Firm does not make a market in Oxford BioMedica PLC as of the date of this research report.

H.C. Wainwright & Co., LLC and its affiliates, officers, directors, and employees, excluding its analysts, will from time to time have long or short positions in, act as principal in, and buy or sell, the securities or derivatives (including options and warrants) thereof of covered companies referred to in this research report.

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