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News Update


Biopharma Hits Milestone in Starting Enrollment for NASH Clinical Trial
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The company will discuss the trial when it hosts a conference call about this specific disease indication in April.

DURECT Corp. (DRRX:NASDAQ) announced in a news release that enrollment began for its Phase 1b nonalcoholic steatohepatitis (NASH) trial.

This is a multicenter, open-label study will evaluate the company's lead drug, DUR-928, in patients with NASH, a complex, chronic liver disease. Three doses—low, middle and high—of DUR-928 will be assessed for safety, pharmacokinetics and signs of biological activity.

A total of 60 patients will be enrolled, 20 per dose. Each patient will receive their assigned dose of DUR-928 for 28 consecutive days. DURECT plans to release initial study data in H2/19.

"[With] this endogenous molecule with a novel mechanism of action, it will be intriguing to see what biological signals are generated in this multidose study, especially given what was previously reported in the single-dose study," Dr. Brent Tetri, professor of internal medicine at Saint Louis University, said in the release.

Tetri will deliver a talk on NASH and answer questions during a conference call hosted by DURECT at 11 a.m. EST on Wednesday, April 17. The company will also discuss its development plan for DUR-928 on the call.


1) Doresa Banning compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. She or members of her household own securities of the following companies mentioned in the article: None. She or members of her household are paid by the following companies mentioned in this article: None.
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