ProMIS Neurosciences Inc. (PMN:TSX; ARFXF:OTCQB) has issued a white paper in association with its participation in the 2018 Alzheimer's Association International Conference (AAIC), according to a July 31 press release. The company made a poster presentation at the conference regarding its lead candidate, humanized PMN310, which it says "shows unrivaled selectivity for native toxic AβO derived from human AD brains, with no off-target binding to Aβ monomers or plaque."
At the AAIC, one area of focus was "the causative role of amyloid-beta oligomers (AβO) in the development and progression of Alzheimer's disease (AD) and the importance of neutralizing AβO toxicity represented a common theme across multiple oral presentations and posters," the company stated.
The ProMIS white paper, titled "State of the Art at AAIC 2018," addresses that theme, exploring the idea that "targeting toxic amyloid-beta oligomers offers renewed hope for treatment of Alzheimer's disease."
"We believe the oligomer selectivity of PMN310 supports a potential best in class product profile compared to other therapeutic antibodies currently showing promising results in clinical trials," ProMIS President and CEO Dr. Elliot Goldstein stated.
Humanized PMN310 "is on track to enter Phase 1 clinical testing in the second half of 2019 and will include biomarker assessment as an integral part of the study design," according to the company.
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