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Pharma Developer Finds Ifenprodil Reduces Interleukin 6 in Phase 2b/3 COVID Trial
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Algernon Pharmaceuticals reported that Ifenprodil was shown to reduce interleukin 6 in its Phase 2b/3 COVID-19 Study, which the company states may have positive implications for its use in its ongoing Phase 2 trial of Ifenprodil for treatment of idiopathic pulmonary fibrosis and chronic cough.

Algernon Pharmaceuticals Inc. (AGN:CSE; AGNPF:OTCQB; AGW:FSE) announced in a news release that "NP-120 (Ifenprodil) reduced interleukin 6 (IL-6) with statistical significance in its recent Ifenprodil Phase 2b/3 COVID-19 trial, which may be informative for the company's ongoing Phase 2 trial of Ifenprodil for idiopathic pulmonary fibrosis (IPF) and chronic cough."

The firm advised that one of the key biomarkers measured and analyzed in its COVID-19 trial was the change in IL-6 levels. The company stated that results in the study showed that "from baseline to day five, IL-6 was reduced in the 20 mg treatment arm by 267 ng/L, versus 7 ng/L in the standard of care arm."

Algernon Pharmaceuticals explained that "IL-6 acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine and is encoded by the IL-6 gene." The firm noted that IL-6 is known to sometimes promote fibrosis and cause chronic inflammation and is frequently elevated in IPF patients.

Based upon the significant findings in the COVID trial, the company now believes that the positive effects of Ifenprodil on IL-6 may could perhaps prove to be beneficial as a potential therapeutic treatment for IPF.

Algernon mentioned in a recent news release that it has met 50% of its target enrollment for its Phase 2 Ifenprodil trial for use in IPF and chronic cough. The company indicated that it will be closely monitoring changes in IL-6 in the study in addition to other relevant markers of fibrosis including C-reactive protein and collagen pro-peptides.

The company stated that at present it is not making any claims, either express or implied, that Ifenprodil possesses the capability of containing, curing or eliminating SARS-CoV-2, which is commonly referred to as COVID-19 or the coronavirus.

Algernon Pharmaceuticals is a drug re-purposing company that specializes in finding new applications for already approved drugs and other natural compounds. The firm may create new formulations and conduct human clinical trials as needed to secure new or expanded use regulatory approvals in global markets. The company advised that to avoid off label prescription writing, it selects compounds for exploration and experimentation that have never been previously approved in either Europe or the United States.


1) Stephen Hytha compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. He or members of his household own securities of the following companies mentioned in the article: None. He or members of his household are paid by the following companies mentioned in this article: None.
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