Algernon Pharmaceuticals Inc. (AGN:CSE; AGNPF:OTCQB; AGW:FSE) announced in a news release the Data and Safety Monitoring Board (DSMB) approved continuation of its multinational Phase 2b/3 clinical trial of NP-120, or Ifenprodil, as a COVID-19 treatment.
This decision "confirms what we had previously identified regarding Ifenprodil's longstanding safety history," Algernon Pharmaceuticals CEO Christopher J. Moreau said in the release.
The Phase 2b portion of the study is currently in progress. "Patients are being randomized in a one-to-one manner and are either being treated using an existing standard of care, or standard of care plus Ifenprodil 60 mg (taken as one 20 mg tablet three-times daily) for one arm or standard of care plus Ifenprodil 120 mg (taken as two 20 mg tablets three-times daily) for two weeks," the company stated. "Over the testing period, doctors will observe whether there is an improvement in a number of secondary endpoints, including mortality, blood oxygen levels, time spent in intensive care and time to mechanical ventilation."
The company noted that the cytokine storm that leads to COVID-19-associated loss of lung function and death results from T-cells releasing cytokines in the lungs. Vancouver-based Algernon believes that Ifenprodil, an NMDA inhibitor, can reduce the release of cytokines in the lungs.
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