ProMIS Neurosciences Inc. (PMN:TSX; ARFXF:OTCQB) announced in a news release it shared data on its lead candidate PMN310, for Alzheimer's disease, at the annual Alzheimer's Association International Conference (AAIC) held July 14 to 18.
On July 18, the company's chief development officer, Dr. Johanne Kaplan, gave a talk on the therapeutic potential of PMN310 against the toxic oligomer form of amyloid beta, a root cause of Alzheimer's disease. She showed PMN310's ability in vitro to stop the spread and toxicity of amyloid beta's toxic oligomer form, and in vivo, to prevent it from inducing loss of memory and to reduce inflammation and synaptic loss.
She pointed out the drug compares favorably with other amyloid beta-targeted antibodies. PMH310 does not bind to amyloid beta deposits in the brains of Alzheimer's disease patients, and it binds more selectively to the toxic form of amyloid beta.
Kaplan commented in the release about the sentiment at the recent AAIC meeting. "This year's gathering was arguably one of the most significant as the research community pivots from a year of discouragement and failure toward hope," she said. "New, incredibly promising therapy development efforts are underway to target the correct, toxic form of amyloid beta, advance new biomarkers that can better identify promising therapy candidates early and mature understanding of new, emerging targets such as tau and sources of neuroinflammation."
ProMIS made a second presentation at the AAIC conference, it also announced. In a poster presentation on July 17, the company's chief scientific officer, Dr. Neil Cashman, "demonstrated the role of toxic, misfolded TDP43 as a root cause of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia" and delivered data on how ProMIS' preclinical ALS program selectively targets it, the release noted.
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